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GENTAUR Europe

 GENTAUR Europe BVBA
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45 
Fax 0032 16 50 90 45
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Gentaur Bulgaria

 GENTAUR BULGARIA
53 Iskar Str. 1191 Kokalyane, Sofia
Tel 0035924682280 
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    GENTAUR France

     GENTAUR France SARL
    9, rue Lagrange, 75005 Paris 
    Tel 01 43 25 01 50 
    Fax 01 43 25 01 60
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    Gentaur Germany

      GmbH Marienbongard 20
    52062 Aachen Deutschland
    Tel (+49) 0241 56 00 99 68 
    Fax (+49) 0241 56 00 47 88 
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    Gentaur London

     GENTAUR Ltd. 
    Howard Frank Turnberry House 
    1404-1410 High Road 
    Whetstone London N20 9BH 
    Tel 020 3393 8531 
    Fax 020 8445 9411
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    GENTAUR Poland

     GENTAUR Poland Sp. z o.o. 

    ul. Grunwaldzka 88/A m.2

    81-771 Sopot, Poland
    Tel  058 710 33 44
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    GENTAUR Nederland

     GENTAUR Nederland BV
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    Tel 0208-080893 
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     GENTAUR SRL IVA IT03841300167

    Piazza Giacomo Matteotti, 6, 24122 Bergamo
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    Gentaur Serbia

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    Other countries
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    Articles

    CACOREADY

    A CELL-BASED AND READY-TO-USE CONCEPT FOR IN VITRO INTESTINAL ABSORPTION EVALUATION
    CacoReady™ is an innovative cell-based and ready-to-use kit. The kit consists of 24 and 96 insert-integrated permeable support seeded with differentiated and polarized Caco-2 barriers on polycarbonate microporous filters. CacoReady™ Allows in vitro intestinal absorption evaluation of drug targets. CacoReady™ is flexible since plates can be used up to 5 days after ideal cell barrier differentiation at day 21. CacoReady™ is a time and cost-saving tool for early stage drug discovery and development.

    BENEFITS
    - Provides 21-day cell barrier allowing reduction of in-house maintenance and handling of Caco-2 cell cultures.
    - High flexibility as the kit is useable up to 5 days after after 21-day cell barrier differentiation.
    - High reproductibility.
    - Time saving and cost-effective.
    - Adaptable to automated procedures and High Throughtput Screening.
    - Easy and clean handling.
    - Full cell functionality after transportation.
    - Shipping medium easy to remove by liquefactionat 37ºC.

    FEATURES
    - Cell-based.
    - Ready-to-use.
    - 24 and 96-HTS insert–integrated plate format.
    - Exclusive solid shipping medium.

    APPLICATIONS
    - Evaluation of: oral absorption efficiency, oral bioavailability and oral toxicity.
    - Study of mechanisms involved in oral and intestinal absorption.
    - Suitable for research on new delivery systems.
    - Studies of Drug Transporters and Drug-Drug Interaction. 

    CACOGOBLET

    A MUCUS SECRETING READY-TO-USE CONCEPT FOR IN VITRO INTESTINAL ABSORPTION EVALUATION
    CacoGoblet, a mucus-secreting ready-to-use kit. The kit consists of 24 and 96-well permeable supports seeded with differentiated polarized Caco-2 and human goblet cells.
    CacoGoblet, allows in vitro intestinal absorption evaluation of drug targets in a barrier physiologically closer to the intestinal epithlium. 
    CacoGoblet is flexible, since plates can be used up to 5 days after ideal cell barrier differentation at day 21, being a time and cost-saving tool for early stage drug discovery and development.

    BENEFITS
    - Mucus secreting CacoGoblet represents a more predictive model for compounds or formulations with passive diffusion transport pathway.
    - CacoGoblet allows end-users to avoid in-house maintenance and handling of cell cultures, thus reducing operating cost.
    - The kit has been designed to provide a user-friendly and suitable tool for High Throughput automated procedures.
    - CacoGoblet provides a 21-day barrier.
    - Out exclusive shipping medium ensures the stability of barrier properties.
    - High flexibility as the kit useable up to 5 days after 21-day cell barrier differentation.
    - Shipping medium is easy to remove by liquefaction at 37ºC.

    FEATURES
    - Cell-based.
    - Ready-to-use.
    - 24 and 96-HTS insert–integrated plate format.
    - Exclusive solid shipping medium.

    APPLICATIONS
    - Evaluation of oral absorption efficiency, oral bioavailability and oral toxicity.
    - Adaptation to High Throughput Screening of target compounds.
    - Study of mechanisms involved in oral and intestinal absorption
    - Suitable for research on new delivery systems.

    PREADYPORT-MDR1

    A NOVEL READY-TO-USE SYSTEM FOR IN VITRO DRUG TRANSPORTER EVALUATION
    Monolayer assays using transfected MDCKII-MDR1 cells are widely recognzied tools, acknowledged by the FDA, to study the interaction of drugs with the P-pg/MDR1 transporter. The MDCKII-MDR1 monolayer system is suitable for performing both substrate and inhibition assessments and is often used to model the net transport events of important fluid compartment barrriers in the organism that express P-gp/MDR1 at a high level, such as the blood-brain-barrier and the intestine. PreadyPort-MDR1 kits contains 24-insert integrated plates with differentiated MDCKII cells expressing MDR1, as well as the parental cell line. The innovative shipping medium, preserves the properties of the barrier throughout transportation. The first member of the PreadyPort series, the PreadyPort-MDR1™kit is revolutionary in providing a ready-to-use tool for MDCKII-MDR1 monolayer assays.The kit will allow researchers to perform BCRP interaction studies on monolayers without bothering about cell-line licensing and culturing.

    FEATURES
    Differentiated MDCKII-BRCP barrier (11 days system)
    Flexibility: the kit can be used up to 7 days after reception.
    24 insert-integrated plate format.
    Up to 4 days of transportation and storage at room temperature in propietary shipping medium.
    Shipping medium is easy to remove after liquefication at 37ºC
    Sample Assay Protocol and Plate Layouts.
    Available under a Limited Single-use License without extra charge.

    BENEFITS
    - Available on demand.
    - Ready-to-use
    - User-friendly and easy-handling system
    - Adaptable to automation
    - Transporter experiments without in-house cell propagation.
    - Transporter experiments without in-house cell line development, or acquisition.

    APPLICATIONS
    - BCRP substrates assessments (direct transport studies).
    - BCRP inhibition assessment (drug-drug interactions)
    - Models the net transport events of barriers like the human blood-brain-barrier and the intestine.

    PREADYPORT-BCRP

    A NOVEL READY-TO-USE SYSTEM FOR IN VITRO DRUG TRANSPORTER EVALUATION
    Membrane transporters can be major determinants of the pharmacokinetic, safety and efficacy profile of drugs. Monolayer assays using transfected MDCKII-BRCP (ABCG2) cells have been widely recognized tools, acknowledged by the ITC1 , to study the interaction of drugs with the BCRP transporter. This system is suitable for performing both inhibition and substrate assessments. MDCKII-BCRP is often used to model the net transport events of important fluid compartment barriers in the organism that express BCRP at high level. BCRP transporter is present in the blood-brain-barrier, intestine, liver, kidney, testis and mammary tissue.

    FEATURES
    - Differentiated MDCKII-BRCP barrier (11 days system)
    - Flexibility: the kit can be used up to 7 days after reception.
    - 24 insert-integrated plate format.
    - Up to 4 days of transportation and storage at room temperature in propietary shipping medium.
    - Shipping medium is easy to remove after liquefication at 37ºC
    - Sample Assay Protocol and Plate Layouts.
    - Available under a Limited Single-use License without extra charge.

    BENEFITS
    - Available on demand.
    - Ready-to-use
    - User-friendly and easy-handling system
    - Adaptable to automation
    - Transporter experiments without in-house cell propagation.
    - Transporter experiments without in-house cell line development, or acquisition.

    APPLICATIONS
    - BCRP substrates assessments (direct transport studies).
    - BCRP inhibition assessment (drug-drug interactions)
    - Models the net transport events of barriers like the human blood-brain-barrier and the intestine.

    ISOPYPTOX

    A NOVEL CELL BASED AND READY-TO-USE CONCEPT FOR IN VITRO EVALUATION OF BIOTRANSFORMATION-MEDIATED METABOLIC TOXICITY
    IsoCyp-Tox is an innovative cell-based and ready-to-use kit. The kit consists of 96-well plates seeded with the hepatic cell line HepG2 transiently transduced with individual human CYP450 isoforms, making these cells metabolically competent. IsoCyp-Tox allows in vitro detection and screening of biotransformation-mediated toxicity of lead and drug targets in just one single experiment. IsoCyp-Tox is powerful as well as time and cost-saving tool during hit to lead and lead optimization phases in early stage of drug discovery and development.

    APPLICATIONS
    - Early detection and screeting of potential bioactivation-dependent acute toxicity of target compunds.
    - Identification of CYP isoforms involved in potential production of toxic metabolites
    - Metabolic activation screening 

    BENEFITS
    - Suitable to current toxicity end-points (MTT,WST,LDH,ATP, etc) without specific know-how.
    - Cost-effective and time saving due to reduction of in-house maintenance and handling of cell cultures.
    - Identification of specific CYPs involved in potential production of toxic metabolites in jus one experiment
    - Designed to allow dose-response studies & IC50 curve fitting at early stage.
    - High reproducibility
    - Adaptable to automated procedures and High Throughput Screening.
    - Available for just-in-time use
    - Similar or even higher CYP activity levels than those observed in fresh human hepatocytes
    - Shipping medium easily to remove by liquefaction at 37ºC

    FEATURES
    - Cell-based.
    - Ready-to-use.
    - Single human CYP450 isoform expression (3A4, 2E1, 1A2, 2A6)
    - High CYP450 isoform activities
    - 96-well plate format
    - Customizable plate design
    - Exclusive solid shipping medium