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    Monday, 22 July 2013 12:08

    ADWX-1: Kv1.3 blocker

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    ADWX-1 is an optimised synthetic analog of the scorpion peptide BmKTx. ADWX-1 is known to block voltage-gated Kv1.3 channel with a high affinity (IC50 = 1.89 pM) and selectivity (340 fold greater affinity than for voltage-dependent ).ADWX-1 inhibits CD4+ CCR7- T-cell proliferation. ADWX-1 is an interesting therapeutic candidate to treat auto-immune disorders such as multiple sclerosis, type-1 diabetes, rheumatoid arthritis and psoriasis. This peptide is a valuable tool for studying the structure-function of Kv1.3 channel and auto-immunity pathways.

    Product Specifications

    AA sequence: Val-Gly-Ile-Asn-Val-Lys-Cys7-Lys-His-Ser-Arg-Gln-Cys13-Leu-Lys-Pro-Cys17-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys27-Thr-Asn-Gly-Lys-Cys32-His-Cys34-Thr-Pro-Lys-OH
    Disulfide bonds between: Cys7-Cys27, Cys13-Cys32, Cys17-Cys34
    Length (aa): 37
    Formula: C169H281N57O46S7 
    Molecular Weight: 4071.90 Da 
    Purity rate: > 98%
    Appearance: White lyophilized solid
    Solubility: water and saline buffer
    CAS number: not available
    Source: Synthetic

    Catalog N° 13ADW001

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