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Friday, 08 November 2013 16:58

New Melanoma Panels

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Each antibody for melanoma is available as a 2ml, 7ml, or 25ml ready-to-use antibody as well as in concentrated form.  Perhaps the most exciting antibody is our pan Melanoma which contains four different clones in order to make the cocktail more sensitive and also more valuable as a diagnostic tool for metastatic melanoma.

Product List:

Melanoma; Pan (Concentrate)

Species: Mouse
Clones: MART-1; Clone M2-7C10, MART-1; Clone M2-9E3, Tyrosinase; Clone T311, Melanoma: HMB45.
Isotype: Mouse IgG1
Species Reactivity: Human.
Positive Control: Human Melanoma
Specificity: HMB45 has been shown to be a very specific marker for melanomas.
 

Melanoma; Pan (Ready-To-Use)

Species: Mouse
Clones: MART-1; Clone M2-7C10, MART-1; Clone M2-9E3, Tyrosinase; Clone T311, Melanoma: HMB45.
Isotype: Mouse IgG1
Species Reactivity: Human.
Positive Control: Human Melanoma
Specificity: HMB45 has been shown to be a very specific marker for melanomas.

MART-1; Clones M2-7C10 & M2-9E3 (Ready-To-Use)

Species: Mouse
Clones: M2-7C10 & M2-9E3
Isotype: Mouse IgG2b, kappa
Species Reactivity: Human.
Positive Control: Human Melanoma.
Specificity: MART-1 has been shown to be a very specific marker for melanomas.

MART-1; Clones M2-7C10 & M2-9E3 (Ready-To-Use)

Species: Mouse
Clones: M2-7C10 & M2-9E3
Isotype: Mouse IgG2b, kappa
Species Reactivity: Human.
Positive Control: Human Melanoma.
Specificity: MART-1 has been shown to be a very specific marker for melanomas.

Tyrosinase; Clone T311 (Concentrate)

Species: Mouse
Clone: T311
Isotype: Mouse IgG1
Species Reactivity: Human.
Positive Control: Human Melanoma
Specificity: Tyrosinase has been shown to be a very specific marker for melanomas, not cross reacting with other tumors or normal tissues tested.

Tyrosinase; Clone T311 (Ready-To-Use)

Species: Mouse
Clone: T311
Isotype: Mouse IgG1
Species Reactivity: Human.
Positive Control: Human Melanoma
Specificity: Tyrosinase has been shown to be a very specific marker for melanomas. Cross reactivity with other tumors or normal tissues tested has not been reported.

MART-1; Clone M2-9E2 (Concentrate)

Species: Mouse
Clone: M2-9E2
Isotype: Mouse IgG2b, Kappa
Species Reactivity: Human, Mouse, Rat.
Positive Control: Metastatic melanoma in lymph nodes.
Specificity: The clone M2-9E2 MART-1 antibody labels melanomas and other tumors showing melanocyte differentiation.

MART-1; Clone M2-9E2 (Ready-To-Use)

Species: Mouse
Clone: M2-9E2
Isotype: Mouse IgG2b, Kappa
Species Reactivity: Human, Mouse, Rat.
Positive Control: Metastatic melanoma in lymph nodes.
Specificity: The clone M2-9E2 MART-1 antibody labels melanomas and other tumors showing melanocyte differentiation.

MART-1; Clone M2-7C10 (Concentrate)

Species: Mouse
Clone: M2-7C10
Isotype: Mouse IgG2b, Kappa
Species Reactivity: Human. Clone M2-7C10 does not react with mouse or rat.
Positive Control: Metastatic melanoma in lymph nodes.
Specificity: The clone M2-7C10 MART-1 antibody labels melanomas and other tumors showing melanocyte differentiation.

MART-1; Clone M2-7C10 (Ready-To-Use)

Species: Mouse
Clone: M2-7C10
Isotype: Mouse IgG2b, Kappa
Species Reactivity: Human. Clone M2-7C10 does not react with mouse or rat.
Positive Control: Metastatic melanoma in lymph nodes.
Specificity: The clone M2-7C10 MART-1 antibody labels melanomas and other tumors showing melanocyte differentiation.

S-100, Clone 4C4.9

  Species: Mouse Monoclonal
Clone: 4C4.9
Isotype: IgG2a
MW: 21-24 kD
Species Reactivity: Human, Cow, Mouse
Positive Control: Melanoma or Schwannoma.

Specificity: Recognizes proteins of 21-24kDa, identified as the A and B subunits of S100 protein. S100 belongs to the family of calcium binding proteins such as calmodulin and troponin C. S100A is composed of an alpha and beta chain whereas S100B is composed of two beta chains. Antibody to S100 stains Schwannomas, ependymomas, astrogliomas, almost all benign and malignant melanomas and their metastases. S100 protein is also expressed in the antigen presenting cells such as the Langerhans cells in skin and interdigitating reticulum cells in the paracortex of lymph nodes. S100 protein is highly soluble and may be eluted from frozen tissue during staining.

Melanoma; Clone HMB45 (Concentrate)

  Species: Mouse
Clone: HMB45
Isotype: Mouse IgG1/ Kappa
Species Reactivity: Human
Positive Control: Human Melanoma
Specificity: HMB45 has been shown to be a very specific marker for melanomas.
 

Melanoma; Clone HMB45

  Species: Mouse Monoclonal
Clone: HMB45
Isotype: IgG1
Species Reactivity: Human. Does not react with dog and rat.
Positive Control: Melanoma

Specificity: By immunohistochemistry, it specifically recognizes a protein in melanocytes and melanomas. Biochemical nature of its antigen is yet not fully characterized. This antibody reacts with junctional and blue nevus cells and variably with fetal and neonatal melanocytes. Intradermal nevi, normal adult melanocytes, and non-melanocytic cells are negative. It does not stain tumor cells of epithelial, lymphoid, glial, or mesenchymal origin.

 

 

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