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    Monday, 24 March 2014 11:08

    Swedish scientists develop model for cancer

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    mice with glioblastomaSwedish researchers have discovered a new method to combat cancer. In scientific journals it a completely new mechanism to fight cancer through the explosion of cancer cells.

    Experts on the science of cancer of the Karolinska Institute in Stockholm said that they were able to cause tumor growth in mice. Through the introduction of the drug they induce growth of a specific type of brain tumor called glioblastoma. Subsequently, after taking another drug they say they were able to prevent tumor development and growth of cancer cells.

    The substance, which is carried out the experiments is called 1 - Vakvinol, which may be administered in tablet form. It has been found that molecules of the particular drug may be incorporated in the cancer cells. In this way they cause the development of a process called vacuolation. In this order the cells swell by extracting fluid from the interstitial space and their incorporation in a vacuole inside the cell, which gradually increases in size. Subsequently, the cancer cell starts to break down, the walls thin and gradually this led to its literal explosion and death.

    Research and their research have been conducted on mice with glioblastoma, which scientists say is true and applicable to other types of cancer cells. This medicament is believed to have the same mechanism of action in humans, but in a different half-life, i.e. the dose in mice and will be different in different time intervals, while in humans will seek saturation and higher plasma concentration for maximum effect.

    The study is the result of many years of research into new methods of drug treatment of cancer, during which scientists have crashed millions of cancer cells particles to determine which of the tested drugs effect will be the strongest. Vakvinol-1 is defined as the definitive drug and scientists say the drug substance to be registered as soon as possible and move in phase 1 clinical trials compared to patients who are suffering from malignant forms of cancer.

    Claims of scientists are complemented by the fact that the experimental conditions in mice implanted tumor cells of human glioblastoma, which subsequently started his own development. Mice were fed with crushed tablets Vakvinol -1 in five consecutive days of drug experimentation. The results show that all six of the eight mice survived after drug administration, while in the control group of the infected mice with human glioblastoma, mortality is recorded as 100% , that is, 30 of each 30 mice were infected reached fatal. Surviving mice with specific therapy lived 80 more days, according to the researchers is equivalent to decades of human life, even allowing for full treatment.

    Professor Patrick Ernfors tissue from the Department of Biology at the Karolinska Institute, Stockholm, said he was proud of the scientific discovery of the research team, because this is an entirely new mechanism to fight cancer, which will be introduced in clinical trials. According to him, possible drug will combat cancer cells in an entirely new pathophysiological mechanism that would protect people from the harmful effects and side effects of other forms of drug therapy of cancers that currently exist.

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