Dear Clients, 

We're happy to announce another one of our great promos, this time the products are different cell culture media:

On 3 April 2013, the China Health and Family Planning Commission notified WHO of an additional four cases of human infection with influenza A(H7N9). The four patients are from Jiangsu province in eastern China. There is no link between the cases.

To date, the total number of confirmed cases of human infection with influenza A(H7N9) virus in China is seven. Three confirmed cases were reported earlier from Shanghai and Anhui provinces, including two deaths.The patients include a 45-year-old woman with illness onset on 19 March 2013; a 48-year-old woman with illness onset on 19 March 2013; an 83-year-old man with illness onset on 20 March 2013; and a 32-year-old woman with illness onset on 21 March 2013. All of these patients are in a critical condition.

More than 160 close contacts of these four cases in Jiangsu province are being closely monitored. Thus far, none of them have developed any symptoms of illness. Retrospective investigation is ongoing into two contacts of one of the cases reported earlier from Shanghai. Both of these contacts developed symptoms of illness; one died and the other recovered. No laboratory confirmation is available for these two contacts.

The Chinese government is actively investigating this event and has heightened disease surveillance for early detection, diagnosis and treatment. Infection prevention and control has been strengthened in health-care settings. Communication efforts between human and animal health and industry sectors have increased. The government has advised the population to maintain good personal hygiene, including frequent handwashing and avoiding direct contact with sick or dead animals.

WHO is in contact with national authorities and is following the event closely. The WHO-coordinated international response is also focusing on work with WHO Collaborating Centres for Reference and Research on Influenza and other partners to ensure that information is available and that materials are developed for diagnosis and treatment and vaccine development. No vaccine is currently available for this subtype of the influenza virus. Preliminary test results provided by the WHO Collaborating Centre in China suggest that the virus is susceptible to the neuraminidase inhibitors (oseltamivir and zanamivir).

At this time there is no evidence of ongoing human-to-human transmission.

WHO does not advise special screening at points of entry with regard to this event, nor does it recommend that any travel or trade restrictions be applied.

For additional information, here is a full view of Gentaur's AIV-related products: 

http://antibody-antibodies.com/search_full.php?search=AIV

Dear Clients, 

We are happy to announce that another promo is available as of today: 

1. Intended Use 

Avian influenza virus H7N9 real time RT-PCR kit is used for the detection of gene H7 and gene N9 of avian influenza A subtype H7N9 in human nasal and pharyngeal secretions and bird fece by using real time PCR systems.

2. Principle of Real-Time PCR

The principle of the real-time detection is based on the fluorogenic 5’nuclease assay. During the PCR reaction, the DNA polymerase cleaves the probe at the 5’ end and separates the reporter dye from the quencher dye only when the probe hybridizes to the target DNA. This cleavage results in the fluorescent signal generated by the cleaved reporter dye, which is monitored real-time by the PCR detection system. The PCR cycle at which an increase in the fluorescence signal is detected initially (Ct) is proportional to the amount of the specific PCR product. Monitoring the fluorescence intensities during Real Time allows the detection of the accumulating product without having to re-open the reaction tube after the amplification.

3. Product Description

Highly pathogenic avian influenza (HPAI) caused by certain subtypes of influenza A virus in animal populations, particularly chickens, poses a continuing global human public health risk. Direct human infection by an avian influenza A (H5N1) virus was first recognized during the 1997 outbreak in Hong Kong. The avian influenza virus H7N9 is one subgroup among the larger group of H7 viruses. Some cases of human infection with H7N9 virus in China are confirmed till early April of 2013.

Avian influenza virus H7N9 real time RT-PCR kit contains a specific ready-to-use system for the detection of avian influenza virus H7N9 by Reverse Transcription Polymerase Chain Reaction (RT-PCR) in the real-time PCR system. The master contains Super Mix for the specific amplification of the avian influenza virus H7N9 RNA. The reaction is done in one step real time RT-PCR. The first step is a reverse transcription (RT), during which the avian influenza virus H9 RNA is transcribed into cDNA. Afterwards, a thermostable DNA polymerase is used to amplify the specific gene fragments by polymerase chain reaction. Fluorescence is emitted and measured by the real time systems´ optical unit during the PCR. The detection of amplified avian influenza virus H7N9 DNA fragment is performed in fluorimeter channel FAM and HEX/VIC/JOE with the fluorescent quencher BHQ1. In addition, the kit contains a system to identify possible PCR inhibition by measuring the FAM fluorescence of the internal control (IC).

 4. Kit Contents

Analysis sensitivity: 1×10³copies/ml；

Note: Analysis sensitivity depends on the sample volume, elution volume, nucleic acid extraction methods and other factors .If you use the RNA extraction kits recommended, the analysis sensitivity is the same as it declares. However, when the sample volume is dozens or even hundreds of times greater than elution volume by some concentrating method, it can be much.

Our Price: EUR 562

For additional information, here is a full view of Gentaur's AIV-related products: 

http://antibody-antibodies.com/search_full.php?search=AIV

Dear Clients,

From the 1^st May until 30^th June we will be offering 20% off the list price of our flashBAC kits.

This includes:

flashBAC 3,5,24 reaction kits.

flashBAC GOLD 3,5,24 reaction kits.

flashBAC ULTRA 3,5,24 reaction kits

flashBAC PRIME 3,5,24 reaction kits.

Hurry and call us today to secure your product!

Smartphones are changing the way people communicate. Now scientists further enhance their applicability in unexpected directions - diagnosis of intestinal parasites.
 
It turns out that using a glass lens, costing $ 8, tape and cheap flashlight, iPhone 4 can be converted into a microscope detecting intestinal parasites according to the World Health Organization affects two billion people.

The scientists have published their results in the American Journal of Tropical Medicine and Hygiene. In the article they describe the analysis of 199 fecal samples using a "tuned" smartphone.
 
Along with the standard light microscope, researchers analyzing and using the "iPhone microscope." The latter turns out to be less sensitive, but much more practical and portable. Scientists believe that it has great potential, especially in poor and remote areas where it is concentrated the bulk of morbidity.

The World Health Organization warned that intestinal parasites affecting mostly in economically depressed areas where they contribute substantially to malnutrition in large populations. Most at risk are children who often develop anemia.
 
Feasibility of smartphones to diagnose intestinal parasitic appears dependent on the type of pathogen and the degree of infestation. For example, using the smartphone to detect 81% of cases of threadworm, but only 14% of cases of small parasitic nematodes, snap on to the intestine with hooks. Scientists say this is due to the different number of eggs that emit various types of environmental faeces.

High-tech gadget successfully diagnosed moderate to severe infestations, but performs poorly in passenger where the sample contains only a few eggs.

Dr. Isaac Bogoch, a specialist in infectious diseases at Toronto General Hospital, and his team are trying to create an alternative test tool by gluing 3-millimeter lens to the iPhone 4S, which scientists routinely use in their daily lives. Bogoch points out, however, that any camera phone with optical zoom can be used for this purpose. As a light source they use less flashlight, working with only one battery. The entire "unit" cost less than $ 15, without of course the price of the phone itself, and can be assembled in less than 5 minutes.

According to team efficiency by 80% for diagnostic tests would make this device practicable. Dr. Bogoch predicted that it can be applied in a work under a limited budget. Furthermore, the team continues to improve device using cheap available materials.

The p40 antibody, catalog number A00112 is provided in concentrated form or in ready-to-use as a 2ml, 7ml, or 25ml.  This antibody is very important as it is helpful in the indication of several different carcinomas and has a wide-spread use in the market.  We have developed the p40 antibody as a replacement antibody for the p63 antibody.  The marker is highly specific for squamous basal cells and is more specific than the p63 marker.  One of the most important functions of this antibody is the ability to differentiate between adeno carcinoma and squamous cell carcinoma for lung cancer.  As you are aware the difference between those carcinomas will determine what avenue of treatment will be applied.  The p40 is specific for indication of the squamous cell carcinoma.  We will soon be releasing our Napsin A antibody for the adeno carcinoma.  These two antibodies work well in conjunction with one another and they will help the pathologist determine what method of treatment is necessary.

The p40 is also an excellent antibody in the use of prostate cancer.  In the early stages of prostate cancer the basal cells inside the ducts will be stained by the p40.  This will help indicate the prostatic intraepithelial neoplasia (PIN) that is considered to be a pre-malignancy as it is a carcinoma in situ of the prostatic glands.  As the cancer progresses the basal cells will be seen throughout the tissue as the cells become invasive.  This antibody can help determine the stage of carcinoma by indicating locations of the basal cells that are stained.

The p40 antibody is also being used with breast cancer as the antibody will stain myoepithelial cells along the ducts of the mammary glands.  This antibody is excellent in determining if Atypical ductal hyperplasia (ADH) is present which can indicate a risk factor for breast cancer and serves as early detection of breast cancer.  This marker will also indicate Ductal Carcinoma in Situ (DCIS) similar to the way it works on prostate cancer.  This is the most common non-invasive type of breast cancer.  The marker will indicate DCIS by highlighting that the cells are still within the ducts.  As breast cancer progresses and becomes invasive those ducts will breakdown and the myoepithelial cells will be seen throughout the tissue and become Invasive Ductal Carcinoma (IDC). 

p40 (p63 Delta); Polyclonal (Ready-To-Use)

Species: Rabbit
Clone: Polyclonal
Isotype: Rabbit IgG
Species Reactivity: Human.
Cellular Localization: Nuclear.
Specificity: The new marker p40 (p63 delta) is highly specific for squamous basal cells.

 Data sheet | MSDS

p40 (p63 Delta); Polyclonal (Concentrate)

Species: Rabbit
Clone: Polyclonal
Isotype: Rabbit IgG
Species Reactivity: Human.
Cellular Localization: Nuclear.
Specificity: The new marker p40 (p63 delta) is highly specific for squamous basal cells.

Data sheet | MSDS