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What is the difference between viruses and bacteria?
Infectious diseases caused by microbes . These are small organisms that are invisible to the naked eye , and " burst " in the body , in order to reproduce . The symptoms caused by the infection will depend on the location , the nature of the infection and the type of microbe .
The two main types of microbes are bacteria and viruses. Viruses are the smallest size of all germs. They can " attack " almost every living organism . Viruses used for the host of other organisms , such as man. This means that the virus invades a cell in the body and parts thereof used in order to reproduce .
Thus produced hundreds of new viruses which can spread throughout the body. They can also infect new organisms. Viruses can not survive outside the host organism for long. Can live for several seconds to a few minutes after you leave .
Bacteria are much larger size of viruses. They live almost everywhere , and many of them do not cause infections. Bacteria reproduce by division. If conditions are favorable - temperature, nutrient availability - some species can reproduce every 20 minutes.
Intestines contain a large number of bacteria. Usually they do not cause problems. In many cases even useful - for example, there are bacteria that aid digestion. However , if the immune system is weak , may occur problems such as diarrhea , constipation or cramping.
Viruses and bacteria can cause infection. Local infection leads to redness and swelling . The fabric may also become warm and painful. Typical symptoms of a viral or bacterial infection include fever , fatigue and weakness . Overall, the viral infection is simple and complaints subside on its own.
It is difficult to destroy viruses. Specific medications have been developed that are aimed at specific types .
Bacterial infections also usually resolves on its own. If this is not the case, your doctor may prescribe antibiotics.
It is important to prevent the spread of germs. For this purpose good hygiene plays an important role .
Researchers develop more effective drug for hepatitis-C
Medicament for the treatment of hepatitis C, developed by Gilead Sciences, received a positive evaluation by the Administration Food and Drug Administration in the U.S..
A positive response by the administration due to the success that the medicament is accomplished by treatment of the disease - more patients are cured in a shorter period of time compared with other drugs in the market.
Studies have shown that adding the drug to Sofosbuvir other prescribed medication is able to cure 90% of patients within 12 weeks, reports the Associated Press. So far no evidence of side effects associated with taking Sofosbuvir.
Since 1986 suffering from hepatitis C treated with interferon alpha protein. However, it is not suitable for everybody, and the positive outcome of the treatment was observed in less than half of the patients who take it.
On the other hand, side effects include depression, symptoms resemble those of the flu, such as fever, fatigue and headache. In some cases, they may even be exacerbated to the extent that may be necessary to slow or stop the treatment.
In 2011, the Administration has approved two drugs that can be used as an add-on to treat the most common type of hepatitis C. Studies have found that the drugs increase the number of patients cured by 65 - 75% of. Recently, however, pharmaceutical companies insist on medications that do not contain interferon.
Hepatitis C is a blood disorder that causes inflammation of the liver. Around 70-80% of people with hepatitis C do not notice any symptoms.
When they are present include: pain in the right upper abdomen, dark urine, fever, jaundice, nausea and vomiting. People with acute hepatitis C may develop a chronic infection.
Chronic hepatitis C can cause cirrhosis of the liver and is a leading factor in the development of liver cancer cherry.
Toxoplasma-infected mice remain unafraid of cats even after parasite clearance
Chronic infection with the parasite Toxoplasma gondii can make mice lose their innate, hard-wired fear of cats. This loss of their innate fear may persist after the parasite is no longer detectable in their brains, suggesting that initial infection may cause permanent changes in the mechanisms underlying their fear of predators. The results are published September 18 in the open access journal PLOS ONE by Wendy Ingram and colleagues from the University of California, Berkeley.
The Toxoplasma parasite can be deadly, causing spontaneous abortion in pregnant women or killing immune-compromised patients, but it has even stranger effects in mice.
Infected mice lose their fear of cats, which is good for both cats and the parasite, because the cat gets an easy meal and the parasite gets into the cat's intestinal track, the only place it can sexually reproduce and continue its cycle of infection.
New research by graduate student Wendy Ingram at the University of California, Berkeley, reveals a scary twist to this scenario: the parasite's effect seem to be permanent. The fearless behavior in mice persists long after the mouse recovers from the flu-like symptoms of toxoplasmosis, and for months after the parasitic infection is cleared from the body, according to research published today (Sept. 18) in the journal PLOS ONE.
"Even when the parasite is cleared and it's no longer in the brains of the animals, some kind of permanent long-term behavior change has occurred, even though we don't know what the actual mechanism is," Ingram said. She speculated that the parasite could damage the smell center of the brain so that the odor of cat urine can't be detected. The parasite could also directly alter neurons involved in memory and learning, or it could trigger a damaging host response, as in many human autoimmune diseases.
Ingram became interested in the protozoan parasite, Toxoplasma gondii, after reading about its behavior-altering effects in mice and rats and possible implications for its common host, the domesticated cat, and even humans. One-third of people around the world have been infected with Toxoplasma and probably have dormant cysts in their brains. Kept in check by the body's immune system, these cysts sometimes revive in immune-compromised people, leading to death, and some preliminary studies suggest that chronic infection may be linked to schizophrenia or suicidal behavior.
Pregnant women are already warned to steer clear of kitty litter, since the parasite is passed through cat feces and can cause blindness or death in the fetus. One main source of spread is undercooked pork, Ingram said.
With the help of Michael Eisen and Ellen Robey, UC Berkeley professors of molecular and cell biology, Ingram set out three years ago to discover how Toxoplasma affects mice's hard-wired fear of cats. She tested mice by seeing whether they avoided bobcat urine, which is normal behavior, versus rabbit urine, to which mice don't react. While earlier studies showed that mice lose their fear of bobcat urine for a few weeks after infection, Ingram showed that the three most common strains of Toxoplasma gondii make mice less fearful of cats for at least four months.
Using a genetically altered strain of Toxoplasma that is not able to form cysts and thus is unable to cause chronic infections in the brain, she demonstrated that the effect persisted for four months even after the mice completely cleared the microbe from their bodies. She is now looking at how the mouse immune system attacks the parasite to see whether the host's response to the infection is the culprit.
"This would seem to refute – or at least make less likely – models in which the behavior effects are the result of direct physical action of parasites on specific parts of the brain," Eisen wrote in a blog post about the research.
"The idea that this parasite knows more about our brains than we do, and has the ability to exert desired change in complicated rodent behavior, is absolutely fascinating," Ingram said. "Toxoplasma has done a phenomenal job of figuring out mammalian brains in order to enhance its transmission through a complicated life cycle."
INFLUENZA B VIRUS (Wisconsin/1/10) Infectious Culture Fluid
PRODUCT DESCRIPTION:
Influenza viruses are enveloped viruses with a diameter of 80-120 nm, and contain a singlestranded, segmented, negative-sense RNA within a nucleocapsid. Influenza virus is propagated in the MDCK cell line. Influenza Culture Fluid is sold in 1.0 mL aliquots, and is shipped on dry ice. Viral culture fluids consist of virus, cells, and media taken directly from the tissue culture flask. Each lot of viral culture fluid is assayed for its Tissue Culture Infective Dose (TCID50), and sold with titers >105 U/ml. Custom orders are available, including specific titers and package sizes.
INTENDED USE:
This product is intended for research, product development testing, or quality assurance testing. Viral culture fluids are sold as consumable testing materials, and are not for propagation or commercialization. Applications include:
- Nucleic Acid / Molecular Testing
- Limit of Detection (LOD) Studies
- Cross-reactivity Studies
- Other Viral-based Assays
TIOLOGIC STATUS/BIOHAZARD TESTING:
Influenza virus is a Biosafety Level 2 organism.
PRECAUTIONS:
USE UNIVERSAL PRECAUTIONS when handling this product! Viral Culture Fluid is live and infectious!! This material should be handled as if capable of transmitting infectious agents.
RECOMMENDED STORAGE:
Viral culture fluid is stable for at least one year when stored at -65ºC or below. To avoid repeat freeze-thaws, which could negatively impact product performance, culture fluid should be stored in aliquots upon receipt.
DO NOT USE IN HUMANS!
These products are NOT intended for use in the manufacture or processing of injectable products subject to licensure under section 351 of the Public Health Service Act, or for any other product intended for administration to humans.
INFLUENZA B VIRUS (Massachusetts/2/12) Infectious Culture Fluid
PRODUCT DESCRIPTION:
Influenza viruses are enveloped viruses with a diameter of 80-120 nm, and contain a singlestranded, segmented, negative-sense RNA within a nucleocapsid. Influenza virus is propagated in the MDCK cell line. Influenza Culture Fluid is sold in 1.0 mL aliquots, and is shipped on dry ice. Viral culture fluids consist of virus, cells, and media taken directly from the tissue culture flask. Each lot of viral culture fluid is assayed for its Tissue Culture Infective Dose (TCID50), and sold with titers >105 U/ml. Custom orders are available, including specific titers and package sizes.
INTENDED USE:
This product is intended for research, product development testing, or quality assurance testing. Viral culture fluids are sold as consumable testing materials, and are not for propagation or commercialization. Applications include:
- Nucleic Acid / Molecular Testing
- Limit of Detection (LOD) Studies
- Cross-reactivity Studies
- Other Viral-based Assays
TIOLOGIC STATUS/BIOHAZARD TESTING:
Influenza virus is a Biosafety Level 2 organism.
PRECAUTIONS:
USE UNIVERSAL PRECAUTIONS when handling this product! Viral Culture Fluid is live and infectious!! This material should be handled as if capable of transmitting infectious agents.
RECOMMENDED STORAGE:
Viral culture fluid is stable for at least one year when stored at -65ºC or below. To avoid repeat freeze-thaws, which could negatively impact product performance, culture fluid should be stored in aliquots upon receipt.
DO NOT USE IN HUMANS!
These products are NOT intended for use in the manufacture or processing of injectable products subject to licensure under section 351 of the Public Health Service Act, or for any other product intended for administration to humans.
New front in the war against infection
Although not completely destroy bacterial and viral infections, penicillin has been a revolution in medicine and its introduction has saved hundreds of millions of lives in the last century. It was unique for its broad spectrum of activity. But since its introduction in medical practice so far appeared many new, exotic and constantly evolving strains of viruses and bacteria that are terrible for health capability - develop resistance to even our most powerful antibiotics.
Scientists at the lab "Lincoln" at MIT are about to end this constant race between human antibiotics and antibiotic resistance of microorganisms.
They created a drug that has proven effective against almost all strains of 15 of the most common viruses in the world. Rhinoviruses that cause the common cold, H1N1 flu, stomach viruses, polio virus, dengue fever and other hemorrhagic viruses, causing internal bleeding.
At present there are few drugs which are effective against specific viruses, such as HIV protease inhibitors controlling agent responsible for AIDS. Unfortunately, they are expensive and often - susceptible to viral resistance. Therefore, the researchers introduced a new approach to the problem - light, which searches and finds the infected cells, not with the virus, and with any type of viral agents. Once localized, these cells are destroyed to prevent the spread of infection.
When a virus particle infects a cell, it "distracts" cellular structures and makes them subject to one goal: to create more copies of the virus. They leave the cell, often destroying her in the process and invade new cells for the same purpose. During the process of replication, viruses establish long strands of the double-stranded RNA which is not present in human or animal organisms. The human body has a protective mechanism that is triggered by the detection of similar chains, but many viruses are able to evade detection and cause delayed immune response that usually starts too late.
To prevent this problem, Todd Rider, head of the research group introduced a new strategy against the attackers. According to it, a much more efficient than the current inducing an enhanced immune response would be, if coupled with a protein binding to the foreign RNA of another protein that induces apoptosis - programmed cell death. Similar compounds exist in nature and the team was able to combine them. Because of their natural origin, they are capable of little aid to pass through the cell membranes of all human tissues and cells. When the drug gets into the infected cell, he programmed for self-destruction, but through uninfected cells, this remains intact.
The drug has been proven non-toxic, and its few side effects do not cause serious health threats. It has already passed laboratory and experimental stage and soon became its clinical trials. If they also succeed, scientists are convinced: up to 3 years the drug could be on the market.
They are proud of their successes achieved so far because they believe they have found a "penicillin of the 21st century."
Human Infection With Influenza A(H7N9) in China
On 3 April 2013, the China Health and Family Planning Commission notified WHO of an additional four cases of human infection with influenza A(H7N9). The four patients are from Jiangsu province in eastern China. There is no link between the cases.
To date, the total number of confirmed cases of human infection with influenza A(H7N9) virus in China is seven. Three confirmed cases were reported earlier from Shanghai and Anhui provinces, including two deaths.The patients include a 45-year-old woman with illness onset on 19 March 2013; a 48-year-old woman with illness onset on 19 March 2013; an 83-year-old man with illness onset on 20 March 2013; and a 32-year-old woman with illness onset on 21 March 2013. All of these patients are in a critical condition.
More than 160 close contacts of these four cases in Jiangsu province are being closely monitored. Thus far, none of them have developed any symptoms of illness. Retrospective investigation is ongoing into two contacts of one of the cases reported earlier from Shanghai. Both of these contacts developed symptoms of illness; one died and the other recovered. No laboratory confirmation is available for these two contacts.
The Chinese government is actively investigating this event and has heightened disease surveillance for early detection, diagnosis and treatment. Infection prevention and control has been strengthened in health-care settings. Communication efforts between human and animal health and industry sectors have increased. The government has advised the population to maintain good personal hygiene, including frequent handwashing and avoiding direct contact with sick or dead animals.
WHO is in contact with national authorities and is following the event closely. The WHO-coordinated international response is also focusing on work with WHO Collaborating Centres for Reference and Research on Influenza and other partners to ensure that information is available and that materials are developed for diagnosis and treatment and vaccine development. No vaccine is currently available for this subtype of the influenza virus. Preliminary test results provided by the WHO Collaborating Centre in China suggest that the virus is susceptible to the neuraminidase inhibitors (oseltamivir and zanamivir).
At this time there is no evidence of ongoing human-to-human transmission.
WHO does not advise special screening at points of entry with regard to this event, nor does it recommend that any travel or trade restrictions be applied.
For additional information, here is a full view of Gentaur's AIV-related products:
First Documented Case of Child Cured of HIV
Dr. Deborah Persaud of Johns Hopkins University today described the first documented case of a child being cured of HIV. The landmark findings were announced at the 2013 Conference on Retroviruses and Opportunistic Infections in Atlanta, GA.
Dr. Persaud, an amfAR grantee, detailed the case of a two-year-old child in Mississippi diagnosed with HIV at birth and immediately put on antiretroviral therapy. At 18 months, the child ceased taking antiretrovirals and was lost to follow-up. When brought back into care at 23 months, despite being off treatment for five months, the child was found to have an undetectable viral load. A battery of subsequent highly sensitive tests confirmed the absence of HIV.
Confirmation of the cure was made possible by a grant the Foundation awarded to Dr. Persaud and Dr. Katherine Luzuriaga of the University of Massachusetts in September 2012. The grant allowed Drs. Persaud and Luzuriaga to establish a research collaboratory to explore and document possible pediatric HIV cure cases. The collaboratory includes renowned researchers Drs. Stephen Spector and Doug Richman at the University of California, San Diego; Dr. Frank Maldarelli at the National Cancer Institute; and Dr. Tae-Wook Chun at the National Institute of Allergy and Infectious Diseases.
"The child's pediatrician in Mississippi [Dr. Hannah Gay, a pediatric HIV specialist at the University of Mississippi] was aware of the work we were doing, and quickly notified our team as soon as this young patient's case came to her attention," said Dr. Rowena Johnston, amfAR vice president and director of research. "Because the collaboratory was already in place, the researchers were able to mobilize immediately and perform the tests necessary to determine if this was in fact a case of a child being cured."
According to Dr. Persaud, comprehensive tests have confirmed beyond doubt that both mother and child were HIV positive when the child was born, and today no signs of HIV infection in the child can be detected by the most sensitive means available.
The only other documented case of an HIV cure to date remains that of Timothy Brown, the so-called "Berlin patient." In 2006, while on treatment for HIV, Mr. Brown was diagnosed with leukemia. His physician was able to treat his leukemia with a stem-cell transplant from a person who was born with a genetic mutation causing immunity to HIV infection. Following the transplant, Mr. Brown was able to stop HIV treatment without experiencing a return of his HIV disease.
This new case points to the tantalizing possibility that different populations of HIV-positive people might be cured in different ways. While Mr. Brown's case was the outcome of a complex, high-risk, and expensive series of procedures, this new case appears to have been the direct result of a comparatively inexpensive course of antiretroviral therapy.
"Given that this cure appears to have been achieved by antiretroviral therapy alone," said Dr. Johnston, "it is also imperative that we learn more about a newborn's immune system, how it differs from an adult's, and what factors made it possible for the child to be cured."
The Mississippi case also underscores the importance of identifying HIV-positive pregnant women, expanding access to treatment regimens than can prevent mother-to-child transmission, and of immediately putting infants on antiretroviral therapy in the event that they are born HIV positive.
"We are proud to have played a leading role in bringing this first pediatric HIV cure to light," said amfAR CEO Kevin Robert Frost. "The case is a startling reminder that a cure for HIV could come in ways we never anticipated, and we hope this is the first of many children cured of HIV in the months and years to come."