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GENTAUR Europe

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 GENTAUR BULGARIA
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    peptides-elisa-targatt-culture-pcr-knockin-mouse-targatt-knockinA new study published in the Proceedings of the National Academy of Sciences USA, PNAS, conducted by researchers at the Ruhr University in Bochum, shows how peptides can be designed so that attack bacterial cells.

    Researchers believe that the disposal of pathogenic bacteria could be done without harming human cells.

    Moreover, this type of therapy would reduce the risk of resistance that developed most pathogens to previously applied drugs.

    Previous studies have already shown that many antimicrobial peptides interact with cell membranes of the bacteria and thus perform its microbicidal effect.

    RUB team has turned his attention to the study of a peptide called MP196, which is a group of very small positively charged peptides consisting of four to ten amino acids.

    From previous studies it is known that the MP196 can cope with a variety of bacteria including some that are multi - drug-resistant, but it is unclear exactly how this process is carried out.

    Researchers have demonstrated that prevents MP196 proteins in the cell membrane of the bacteria and thereby distort two key cellular processes: cell wall biosynthesis and cell breathing.

    Through disruption of cell wall biosynthesis, the peptide interferes with the integrity of the bacterial cell, and by interfering with the cellular respiration, distorts the production of ATP, the molecule that stores the energy used by the cell.

    Scientists are confident that the MP196 offers a starting point for developing new drugs that attack specific classes of bacteria without harming human cells, but to be confirmed in their findings need to go a long way.

    The study is part of the development of innovative antibiotics.

    To solve new drugs, federal authorities need detailed information about the procedure and the effects of drugs on both pathogens and on human cells.

    Published in News

    Caspase-3 Assay for Apoptosis Detection in Whole, Living Cells 
    Catalog no. 9125 (25-50 tests)

    flica-660-caspase-3-assay-apoptosis-positive-jurkat-cellsApoptosis is an evolutionarily conserved form of cell suicide mediated by a cascade of proteolytic enzymes called caspases. Pro-apoptotic signals activate the enzymatic cascade resulting in the cleavage of protein substrates, leading to the disassembly of the cell. Caspases have been identified in organisms ranging fromC. eleganstoMembers of the mammalian caspase family of cysteinyl aspartate-specific proteases play distinct roles in apoptosis and inflammation.

    Caspases
    Active caspase enzymes exhibit catalytic and substrate specificities comprised of short tetra-peptide amino acid sequences that must contain an aspartate in the P1 position. These preferred tetra-peptide sequences have been used to derive peptides that specifically compete for caspase binding. In addition to the distinctive aspartate cleavage site at P1, the catalytic domains of the caspases typically require four amino acids to the left of the cleavage site with P4 as the prominent specificity-determining residue. Addition of a fluoromethyl ketone (FMK) to the tetrapeptide results in an irreversible linkage and permanent inactivation of the cysteine protease enzyme. Furthermore, conjugation of a fluorescent moiety at the amino terminus yields a probe that allows for the detection of caspase activity.

    FLICA® 660 Caspase-3 Assay: Detection Mechanism

    The far-red FLICA® 660-DEVD-FMK caspase-3 detection probe is comprised of the preferred affinity peptide sequence (DEVD) targeted by activated caspase-3 and caspase-7, a far-red fluorescent 660 dye label, and a fluoromethyl ketone (FMK) reactive moiety. The resulting fluorescent caspase-3 inhibitor probe forms an irreversible, covalent bond with active caspase-3 enzymes, efficiently labeling the target for detection. Due to its cell permeant nature and fluorescence properties, the far-red FLICA caspase-3 detection probe enables whole cell analysis via common fluorescence detection methods.

    To use FLICA Caspase-3 Assay, add the caspase-3 detection probe directly to suspension cell or tissue culture media, incubate, and wash. The cell permeant, far-red FLICA caspase-3 detection probe will efficiently diffuse into cells and irreversibly bind to activated caspase-3 enzymes, thereby retaining the red signal inside caspase-3-positive cells. Cells not bearing active caspase-3 return to a non-fluorescent status after the wash step.

    The FLICA® 660 caspase-3 detection probe has an optimal excitation at 660 nm and optimal emission range from 680-690 nm. As such, it has demonstrated excellent excitation efficiency with a conventional red HeNe laser with a 633 nm excitation, enabling samples to be analyzed with most flow cytometers and fluorescence microscopes equipped with electronic grey scale image capabilities. Cells labeled with the FLICA® caspase-3 detection probe may be read immediately or preserved for 16 hours using the fixative.

    Cat #: 9125 (25-50 tests)

    Price: 250 Euro (without VAT)

     

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    Published in Promos
    Monday, 22 July 2013 12:08

    ADWX-1: Kv1.3 blocker

    ADWX-1 is an optimised synthetic analog of the scorpion peptide BmKTx. ADWX-1 is known to block voltage-gated Kv1.3 channel with a high affinity (IC50 = 1.89 pM) and selectivity (340 fold greater affinity than for voltage-dependent ).ADWX-1 inhibits CD4+ CCR7- T-cell proliferation. ADWX-1 is an interesting therapeutic candidate to treat auto-immune disorders such as multiple sclerosis, type-1 diabetes, rheumatoid arthritis and psoriasis. This peptide is a valuable tool for studying the structure-function of Kv1.3 channel and auto-immunity pathways.

    Product Specifications

    AA sequence: Val-Gly-Ile-Asn-Val-Lys-Cys7-Lys-His-Ser-Arg-Gln-Cys13-Leu-Lys-Pro-Cys17-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys27-Thr-Asn-Gly-Lys-Cys32-His-Cys34-Thr-Pro-Lys-OH
    Disulfide bonds between: Cys7-Cys27, Cys13-Cys32, Cys17-Cys34
    Length (aa): 37
    Formula: C169H281N57O46S7 
    Molecular Weight: 4071.90 Da 
    Purity rate: > 98%
    Appearance: White lyophilized solid
    Solubility: water and saline buffer
    CAS number: not available
    Source: Synthetic

    Catalog N° 13ADW001

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    Published in Promos
    Monday, 22 July 2013 11:57

    GaTx1

    GaTx1: Toxin Properties

    The GaTx1 peptide was originally isolated from the venom of Leiurus quinquestriatus hebraeus. This peptide is a potent and selective inhibitor of CFTR, an anion selective channel belonging to the ABC transporter superfamily. It was shown to block CFTR channels in a state dependent manner by acting from the internal face of the channel and it is supposed to be a non competitive inhibitor of ATP-dependent channel gating. GaTx1 is a valuable tool to explore the function of CFTR.

    Product Specifications

    AA sequence: Cys1-Gly-Pro-Cys4-Phe-Thr-Thr-Asp-His-Gln-Met-Glu-Gln-Lys-Cys15-Ala-Glu-Cys18-Cys19-Gly-Gly-Ile-Gly-Lys-Cys25-Tyr-Gly-Pro-Gln-Cys30-Leu-Cys32-Asn-Arg-NH2
    Disulfide bonds between: Cys1-Cys18, Cys4-Cys25, Cys15-Cys30, and Cys19-Cys32
    Length (aa): 34
    Formula: C147H224N46O47S96 
    Molecular Weight: 3674.2 Da
    Appearance: White lyophilized solid
    Solubility: water and saline buffer
    CAS number: not available
    Source: Synthetic

    Catalog N: 13GTX001

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    Published in Promos
    Friday, 12 July 2013 17:33

    Obtustatin

    Obtustatin: Toxin Properties

    Obtustatin is a 41 amino acid disintegrin peptide isolated from the venom of the Vipera lebetina obtusa. It is a potent (IC50 = 2 nM) and selective inhibitor of the binding of α1β1 integrin to collagen IV.  Contrary to other known disintegrins, it does not contain the classical RGD sequence. Does not show inhibitory activity toward other integrins, including α2β1, αIIbβ3, αvβ3, α4β1, α5β1, α6β1, and α9β1, α4β7 integrins. Obtustatin potently inhibits angiogenesis in chicken and in mouse model and reduces tumor development by half.

    Product Specifications

    AA sequence: Cys1-Thr-Thr-Gly-Pro-Cys6-Cys7-Arg-Gln-Cys10-Lys-Leu-Lys-Pro-Ala-Gly-Thr-Thr-Cys19-Trp-Lys-Thr-Ser-Leu-Thr-Ser-His-Tyr-Cys29-Thr-Gly-Lys-Ser-Cys34-Asp-Cys36-Pro-Leu-Tyr-Pro-Gly-OH
    (Disulfide bonds between Cys1-Cys10, Cys6-Cys29, Cys7-Cys34 and Cys19-Cys36)
    Length (aa): 41
    Formula: C184H284N52O57S8
    Molecular Weight: 4393.13 Da
    Appearance: White lyophilized solid
    Solubility: aqueous buffer
    CAS number: not available
    Source: Synthetic
    Purity rate: > 97 %

    Catalog N: 10OBT001

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    Published in Promos