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GENTAUR Europe

 GENTAUR Europe BVBA
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45 
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 GENTAUR BULGARIA
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    Wednesday, 24 July 2013 09:41

    New front in the war against infection

    proffemaleAlthough not completely destroy bacterial and viral infections, penicillin has been a revolution in medicine and its introduction has saved hundreds of millions of lives in the last century. It was unique for its broad spectrum of activity. But since its introduction in medical practice so far appeared many new, exotic and constantly evolving strains of viruses and bacteria that are terrible for health capability - develop resistance to even our most powerful antibiotics.

    Scientists at the lab "Lincoln" at MIT are about to end this constant race between human antibiotics and antibiotic resistance of microorganisms.
     
    They created a drug that has proven effective against almost all strains of 15 of the most common viruses in the world. Rhinoviruses that cause the common cold, H1N1 flu, stomach viruses, polio virus, dengue fever and other hemorrhagic viruses, causing internal bleeding.

    At present there are few drugs which are effective against specific viruses, such as HIV protease inhibitors controlling agent responsible for AIDS. Unfortunately, they are expensive and often - susceptible to viral resistance. Therefore, the researchers introduced a new approach to the problem - light, which searches and finds the infected cells, not with the virus, and with any type of viral agents. Once localized, these cells are destroyed to prevent the spread of infection.

    When a virus particle infects a cell, it "distracts" cellular structures and makes them subject to one goal: to create more copies of the virus. They leave the cell, often destroying her in the process and invade new cells for the same purpose. During the process of replication, viruses establish long strands of the double-stranded RNA which is not present in human or animal organisms. The human body has a protective mechanism that is triggered by the detection of similar chains, but many viruses are able to evade detection and cause delayed immune response that usually starts too late.

    To prevent this problem, Todd Rider, head of the research group introduced a new strategy against the attackers. According to it, a much more efficient than the current inducing an enhanced immune response would be, if coupled with a protein binding to the foreign RNA of another protein that induces apoptosis - programmed cell death. Similar compounds exist in nature and the team was able to combine them. Because of their natural origin, they are capable of little aid to pass through the cell membranes of all human tissues and cells. When the drug gets into the infected cell, he programmed for self-destruction, but through uninfected cells, this remains intact.

    The drug has been proven non-toxic, and its few side effects do not cause serious health threats. It has already passed laboratory and experimental stage and soon became its clinical trials. If they also succeed, scientists are convinced: up to 3 years the drug could be on the market.
     
    They are proud of their successes achieved so far because they believe they have found a "penicillin of the 21st century."

     

    Published in News

    RNA-targatt-antibody-antiA single drug may be an effective therapy for a number of different viral diseases such as Ebola and rabies, a new study published in Cell Chemistry and Biology.

    John Connor - a virologist at the University of Boston, USA, and co-author of the article, explains that his research team study the vesicular stomatitis virus, a close relative of the Ebola virus, but not as deadly. It turns out that several viruses, including rabies, mumps, vesicular stomatitis virus and NICA (deadly pathogen spread by bats) use the same method to reproduce in human cells. This led scientists to start looking for a substance that can stop the replication process of these viruses.

    The result - the first broad-spectrum antiviral compound that stops the playback of a variety of viruses through disruption of the synthesis of viral ribonucleic acid. Although up to a medicinal product used in humans will probably take at least several years of laboratory research and as many clinical studies, the discovery is a major breakthrough in anti-infective and, in particular - antivirus, therapy with the potential to change the treatment of many of the most serious viral diseases.

     

    Published in News